产品货号：
Z10365
中文名称：
Aconitase 1/ACO1抗体
英文名称：
Anti-Aconitase 1/ACO1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Aconitase 1/ACO1 Antibody |
| 指标别名 | ACO1;Aconitase;Aconitase 1;aconitase 1;soluble;ACONS;Citrate hydro lyase;Ferritin repressor protein;IRE BP 1;IREB1;IREBP;IREBP1;Iron regulatory protein 1;IRP1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,monkey,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | ACO1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Aconitase 1/ACO1 recombinant protein (Position:M1-D137). |
| 实际分子量 | 98KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The protein encoded by this gene is a bifunctional,cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells.When cellular iron levels are high,this protein binds to a 4Fe-4S cluster and functions as an aconitase.Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate.When cellular iron levels are low,the protein binds to iron-responsive elements (IREs),which are stem-loop structures found in the 5' UTR of ferritin mRNA,and in the 3' UTR of transferrin receptor mRNA.When the protein binds to IRE,it results in repression of translation of ferritin mRNA,and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA.The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions.Alternative splicing results in multiple transcript variants. |
| Uniprot ID | P21399 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | aconitase 1 |
| 蛋白名全称 | Cytoplasmic aconitate hydratase |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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